Digital Companion to C. S. Peirce
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Some Wit, Wisdom & Bewilderment
...the scientific spirit requires a man to be at all times ready to dump his whole cart-load of beliefs, the moment experience is against them. The desire to learn forbids him to be perfectly cocksure that he knows already. Besides positive science can only rest on experience; and experience can never result in absolute certainty, exactitude, necessity, or universality.
The Principal Lessons of the History of Science, c. 1896